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Inner-View of Nanomaterial Incited Protein Conformational Changes: Insights into Designable Interaction.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Mukhopadhyay, Arka 
Basu, Sankar 
Singha, Santiswarup 
Patra, Hirak K 

Abstract

Nanoparticle bioreactivity critically depends upon interaction between proteins and nanomaterials (NM). The formation of the "protein corona" (PC) is the effect of such nanoprotein interactions. PC has a wide usage in pharmaceuticals, drug delivery, medicine, and industrial biotechnology. Therefore, a detailed in-vitro, in-vivo, and in-silico understanding of nanoprotein interaction is fundamental and has a genuine contemporary appeal. NM surfaces can modify the protein conformation during interaction, or NMs themselves can lead to self-aggregations. Both phenomena can change the whole downstream bioreactivity of the concerned nanosystem. The main aim of this review is to understand the mechanistic view of NM-protein interaction and recapitulate the underlying physical chemistry behind the formation of such complicated macromolecular assemblies, to provide a critical overview of the different models describing NM induced structural and functional modification of proteins. The review also attempts to point out the current limitation in understanding the field and highlights the future scopes, involving a plausible proposition of how artificial intelligence could be aided to explore such systems for the prediction and directed design of the desired NM-protein interactions.

Description

Keywords

3206 Medical Biotechnology, 32 Biomedical and Clinical Sciences, Bioengineering, Biotechnology, Nanotechnology, Generic health relevance

Journal Title

Research (Wash D C)

Conference Name

Journal ISSN

2096-5168
2639-5274

Volume Title

2018

Publisher

American Association for the Advancement of Science (AAAS)
Sponsorship
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (706694)