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BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Nguyen, An 
Fedorova, Maria 

Abstract

Lipidomics increasingly describes the quantification using mass spectrometry of all lipids present in a biological sample.  As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment.  Observed changes due to biological differences often encompass large numbers of structurally-related lipids, with these being regulated by enzymes from well-known metabolic pathways.  As lipidomics datasets increase in complexity, the interpretation of their results becomes more challenging.  BioPAN addresses this by enabling the researcher to visualise quantitative lipidomics data in the context of known biosynthetic pathways.  BioPAN provides a list of genes, which could be involved in the activation or suppression of enzymes catalysing lipid metabolism in mammalian tissues.

Description

Keywords

Biosynthetic pathway analysis, LIPID MAPS, Lipidomics, lipid profiling., lipids, Animals, Internet, Lipid Metabolism, Lipidomics, Lipids, Metabolic Networks and Pathways

Journal Title

F1000Res

Conference Name

Journal ISSN

2046-1402
2046-1402

Volume Title

10

Publisher

F1000 Research Ltd