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Functional connectivity in mild cognitive impairment with Lewy bodies.

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cam.issuedOnline2021-04-29
dc.contributor.authorSchumacher, Julia
dc.contributor.authorTaylor, John-Paul
dc.contributor.authorHamilton, Calum A
dc.contributor.authorFirbank, Michael
dc.contributor.authorDonaghy, Paul C
dc.contributor.authorRoberts, Gemma
dc.contributor.authorAllan, Louise
dc.contributor.authorDurcan, Rory
dc.contributor.authorBarnett, Nicola
dc.contributor.authorO'Brien, John T
dc.contributor.authorThomas, Alan J
dc.contributor.orcidSchumacher, Julia [0000-0001-7323-4789]
dc.date.accessioned2021-11-03T16:14:03Z
dc.date.available2021-11-03T16:14:03Z
dc.date.issued2021-12
dc.date.submitted2021-02-23
dc.date.updated2021-11-03T16:14:02Z
dc.descriptionFunder: GE Healthcare; doi: http://dx.doi.org/10.13039/100006775
dc.description.abstractPrevious resting-state fMRI studies in dementia with Lewy bodies have described changes in functional connectivity in networks related to cognition, motor function, and attention as well as alterations in connectivity dynamics. However, whether these changes occur early in the course of the disease and are already evident at the stage of mild cognitive impairment is not clear. We studied resting-state fMRI data from 31 patients with mild cognitive impairment with Lewy bodies compared to 28 patients with mild cognitive impairment due to Alzheimer's disease and 24 age-matched controls. We compared the groups with respect to within- and between-network functional connectivity. Additionally, we applied two different approaches to study dynamic functional connectivity (sliding-window analysis and leading eigenvector dynamic analysis). We did not find any significant changes in the mild cognitive impairment groups compared to controls and no differences between the two mild cognitive impairment groups, using static as well as dynamic connectivity measures. While patients with mild cognitive impairment with Lewy bodies already show clear functional abnormalities on EEG measures, the fMRI analyses presented here do not appear to be sensitive enough to detect such early and subtle changes in brain function in these patients.
dc.identifier.doi10.17863/CAM.77680
dc.identifier.eissn1432-1459
dc.identifier.issn0340-5354
dc.identifier.others00415-021-10580-z
dc.identifier.other10580
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330239
dc.languageen
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1007/s00415-021-10580-z
dc.subjectAlzheimer’s disease
dc.subjectDynamic connectivity
dc.subjectLeading eigenvector dynamic analysis
dc.subjectLewy body dementia
dc.subjectResting-state fMRI
dc.subjectSliding-window analysis
dc.subjectAlzheimer Disease
dc.subjectBrain
dc.subjectCognition
dc.subjectCognitive Dysfunction
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.titleFunctional connectivity in mild cognitive impairment with Lewy bodies.
dc.typeArticle
dcterms.dateAccepted2021-04-24
prism.endingPage4720
prism.issueIdentifier12
prism.publicationNameJ Neurol
prism.startingPage4707
prism.volume268
pubs.funder-project-idAlzheimer’s Research UK (ARUK-PG2015-13)
pubs.funder-project-idNIHR Newcastle Biomedical Research Centre (BH120812, BH120878)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s00415-021-10580-z

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