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Skin Sodium and Hypertension: a Paradigm Shift?

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Selvarajah, Viknesh 


PURPOSE OF REVIEW: Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role. RECENT FINDINGS: Animal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP. Studies in humans have shown that skin could be a buffer for sodium and that skin sodium could be a marker of hypertension and salt sensitivity. Skin sodium storage could represent an additional system influencing the response to salt load and blood pressure in humans.



Blood pressure, Salt, Skin, Sodium, VEGF-C, Animals, Hemodynamics, Humans, Hypertension, Lymphoid Tissue, Macrophages, Magnetic Resonance Spectroscopy, Skin, Sodium, Sodium, Dietary, Vascular Endothelial Growth Factor C

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Curr Hypertens Rep

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Springer Science and Business Media LLC
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Wellcome Trust (207166/Z/17/Z)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation NIHR Addenbrookes Charitable Trust