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Skin Sodium and Hypertension: a Paradigm Shift?

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cam.issuedOnline2018-09-13
cam.orpheus.successThu Jan 30 10:54:34 GMT 2020 - The item has an open VoR version.
dc.contributor.authorSelvarajah, Viknesh
dc.contributor.authorConnolly, Kathleen
dc.contributor.authorMcEniery, Carmel
dc.contributor.authorWilkinson, Ian
dc.contributor.orcidConnolly, Kathleen [0000-0002-9210-2703]
dc.contributor.orcidMcEniery, Carmel [0000-0003-3636-0705]
dc.contributor.orcidWilkinson, Ian [0000-0001-6598-9399]
dc.date.accessioned2018-09-11T17:33:20Z
dc.date.available2018-09-11T17:33:20Z
dc.date.issued2018-09-13
dc.description.abstractPURPOSE OF REVIEW: Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role. RECENT FINDINGS: Animal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP. Studies in humans have shown that skin could be a buffer for sodium and that skin sodium could be a marker of hypertension and salt sensitivity. Skin sodium storage could represent an additional system influencing the response to salt load and blood pressure in humans.
dc.description.sponsorshipBritish Heart Foundation NIHR Addenbrookes Charitable Trust
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.27589
dc.identifier.eissn1534-3111
dc.identifier.issn1522-6417
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280222
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1007/s11906-018-0892-9
dc.subjectBlood pressure
dc.subjectSalt
dc.subjectSkin
dc.subjectSodium
dc.subjectVEGF-C
dc.subjectAnimals
dc.subjectHemodynamics
dc.subjectHumans
dc.subjectHypertension
dc.subjectLymphoid Tissue
dc.subjectMacrophages
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectSkin
dc.subjectSodium
dc.subjectSodium, Dietary
dc.subjectVascular Endothelial Growth Factor C
dc.titleSkin Sodium and Hypertension: a Paradigm Shift?
dc.typeArticle
dcterms.dateAccepted2018-08-14
prism.issueIdentifier11
prism.publicationDate2018
prism.publicationNameCurr Hypertens Rep
prism.startingPage94
prism.volume20
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idWellcome Trust (207166/Z/17/Z)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (None)
rioxxterms.licenseref.startdate2018-09-13
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionofrecord10.1007/s11906-018-0892-9

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