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Three-dimensional MRI evaluation of the effect of bladder volume on prostate translocation and distortion.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Snoj, Ziga 
Gill, Andrew B 
Sushentsev, Nikita 

Abstract

Background The accuracy of any radiation therapy delivery is limited by target organ translocation and distortion. Bladder filling is one of the recognised factors affecting prostate translocation and distortion. The purpose of our study was to evaluate the effect of bladder volume on prostate translocation and distortion by using detailed three-dimensional prostate delineation on MRI. Patients and methods Fifteen healthy male volunteers were recruited in this prospective, institutional review board-approved study. Each volunteer underwent 4 different drinking preparations prior to imaging, with MR images acquired pre- and post-void. MR images were co-registered by using bony landmarks and three-dimensional contouring was performed in order to assess the degree of prostate translocation and distortion. According to changes in bladder or rectum distention, subdivisions were made into bladder and rectal groups. Studies with concomitant change in both bladder and rectal volume were excluded. Results Forty studies were included in the bladder volume study group and 8 in the rectal volume study group. The differences in rectal volumes yielded higher levels of translocation (p < 0.01) and distortion (p = 0.02) than differences in bladder volume. Moderate correlation of prostate translocation with bladder filling was shown (r = 0.64, p < 0.01). There was no important prostate translocation when bladder volume change was < 2-fold (p < 0.01). Moderate correlation of prostate distortion with bladder filling was shown (r = 0.61, p < 0.01). Conclusions Bladder volume has a minimal effect on prostate translocation and effect on prostate distortion is negligible. Prostate translocation may be minimalised if there is < 2-fold increase in the bladder volume.

Description

Keywords

bladder volume, gland deformation, magnetic resonance imaging, prostate distortion, prostate translocation, radiation therapy planning, Adult, Anatomic Landmarks, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Prospective Studies, Prostate, Rectum, Urinary Bladder

Journal Title

Radiol Oncol

Conference Name

Journal ISSN

1318-2099
1581-3207

Volume Title

54

Publisher

Walter de Gruyter GmbH

Rights

All rights reserved
Sponsorship
Royal College of Radiologists (RCR) (unknown)
Cancer Research Uk (None)
The authors acknowledge grant support from the Royal College of Radiologists UK and research support from Cancer Research UK, National Institute of Health Research Cambridge Biomedical Research Centre, Cancer Research UK and the Engineering and Physical Sciences Research Council Imaging Centre in Cambridge and Manchester and the Cambridge Experimental Cancer Medicine Centre.