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Promoting physical activity in a multi-ethnic population at high risk of diabetes: the 48-month PROPELS randomised controlled trial.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Griffin, Simon 
Brennan, Alan 
Dallosso, Helen 
Davies, Melanie J 

Abstract

BACKGROUND: Physical activity is associated with a reduced risk of type 2 diabetes and cardiovascular disease but limited evidence exists for the sustained promotion of increased physical activity within diabetes prevention trials. The aim of the study was to investigate the long-term effectiveness of the Walking Away programme, an established group-based behavioural physical activity intervention with pedometer use, when delivered alone or with a supporting mHealth intervention. METHODS: Those at risk of diabetes (nondiabetic hyperglycaemia) were recruited from primary care, 2013-2015, and randomised to (1) Control (information leaflet); (2) Walking Away (WA), a structured group education session followed by annual group-based support; or (3) Walking Away Plus (WAP), comprising WA annual group-based support and an mHealth intervention delivering tailored text messages supported by telephone calls. Follow-up was conducted at 12 and 48 months. The primary outcome was accelerometer measured ambulatory activity (steps/day). Change in primary outcome was analysed using analysis of covariance with adjustment for baseline, randomisation and stratification variables. RESULTS: One thousand three hundred sixty-six individuals were randomised (median age = 61 years, ambulatory activity = 6638 steps/day, women = 49%, ethnic minorities = 28%). Accelerometer data were available for 1017 (74%) individuals at 12 months and 993 (73%) at 48 months. At 12 months, WAP increased their ambulatory activity by 547 (97.5% CI 211, 882) steps/day compared to control and were 1.61 (97.5% CI 1.05, 2.45) times more likely to achieve 150 min/week of moderate-to-vigorous physical activity. Differences were not maintained at 48 months. WA was no different to control at 12 or 48 months. Secondary anthropometric and health outcomes were largely unaltered in both intervention groups apart from small reductions in body weight in WA (~ 1 kg) at 12- and 48-month follow-up. CONCLUSIONS: Combining a pragmatic group-based intervention with text messaging and telephone support resulted in modest changes to physical activity at 12 months, but changes were not maintained at 48 months. TRIAL REGISTRATION: ISRCTN 83465245 (registered on 14 June 2012).

Description

Keywords

Diabetes prevention, Group-based intervention, Non-diabetic hyperglycaemia, Pedometer, Physical activity, Randomised controlled trial, mHealth, Actigraphy, Diabetes Mellitus, Type 2, Exercise, Female, Humans, Middle Aged, Text Messaging, Walking

Journal Title

BMC Med

Conference Name

Journal ISSN

1741-7015
1741-7015

Volume Title

19

Publisher

Springer Science and Business Media LLC

Rights

All rights reserved
Sponsorship
National Institute for Health Research (NIHR) (via University of Leicester) (RM62G0367)
MRC (MC_UU_00006/6)
This study was funded by the National Institute for Health Research Health Technology Assessment (HTA) Programme (HTA 09/162/02). Accelerometer processing and analysis was supported by the NIHR Leicester Biomedical Research Centre. The costs of delivering the intervention were supported by the NHS Leicester City Clinical Commissioning Group (CCG), NHS West Leicestershire CCG, NHS East Leicestershire and Rutland CCG, Cambridgeshire and Peterborough CCG and NHS England. KK, TY, JH and MJD are supported by the National Institute for Health Research (NIHR) Applied Research Collaboration East Midlands (ARC EM) and the NIHR Leicester Biomedical Research Centre (BRC).