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[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

Published version
Peer-reviewed

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Authors

Bevan-Jones, Richard W 
Cope, Thomas E 
Jones, Simon P 
Hong, Young T 

Abstract

The PET ligand [18F]AV-1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP-43 pathology. Here we assessed [18F]AV-1451 binding in behavioral variant frontotemporal dementia due to a hexanucleotide repeat expansion in C9orf72, characterized by TDP-43 pathology. We show that the C9orf72 mutation increases binding in frontotemporal cortex, with a distinctive distribution of binding compared with healthy controls.

Description

Keywords

5203 Clinical and Health Psychology, 32 Biomedical and Clinical Sciences, 3209 Neurosciences, 52 Psychology, Clinical Research, Neurosciences, Brain Disorders, Rare Diseases, Frontotemporal Dementia (FTD), Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Acquired Cognitive Impairment, Alzheimer's Disease, Neurodegenerative, Alzheimer's Disease Related Dementias (ADRD), Aging, 2.1 Biological and endogenous factors, Neurological

Journal Title

Ann Clin Transl Neurol

Conference Name

Journal ISSN

2328-9503
2328-9503

Volume Title

5

Publisher

Wiley
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
National Institute for Health Research (NIHR) (via Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (DTC-RP-PG-0311-12001)
Wellcome Trust (103838/Z/14/Z)
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Medical Research Council (MR/P01271X/1)
Medical Research Council (MR/K02308X/1)
Engineering and Physical Sciences Research Council (EP/P008224/1)
Medical Research Council (MR/M009041/1)
Medical Research Council (MC_U105597119)
Medical Research Council (MR/M024873/1)
Medical Research Council (MC_UU_00005/12)