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A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.

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cam.issuedOnline2017-05-22
dc.contributor.authorVasiliauskaitė, Lina
dc.contributor.authorVitsios, Dimitrios
dc.contributor.authorBerrens, Rebecca V
dc.contributor.authorCarrieri, Claudia
dc.contributor.authorReik, Wolf
dc.contributor.authorEnright, Anton J
dc.contributor.authorO'Carroll, Dónal
dc.contributor.orcidVasiliauskaitė, Lina [0000-0003-0926-3862]
dc.contributor.orcidVitsios, Dimitrios [0000-0002-8939-5445]
dc.date.accessioned2019-06-17T23:31:45Z
dc.date.available2019-06-17T23:31:45Z
dc.date.issued2017-07
dc.description.abstractIn mice, the pathway involving PIWI and PIWI-interacting RNA (PIWI-piRNA) is essential to re-establish transposon silencing during male-germline reprogramming. The cytoplasmic PIWI protein MILI mediates piRNA-guided transposon RNA cleavage as well as piRNA amplification. MIWI2's binding to piRNA and its nuclear localization are proposed to be dependent upon MILI function. Here, we demonstrate the existence of a piRNA biogenesis pathway that sustains partial MIWI2 function and reprogramming activity in the absence of MILI.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.40813
dc.identifier.eissn1545-9985
dc.identifier.issn1545-9993
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293701
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/nsmb.3413
dc.rightsAll rights reserved
dc.subjectAnimals
dc.subjectArgonaute Proteins
dc.subjectGene Expression Regulation
dc.subjectMice
dc.subjectMice, Knockout
dc.subjectRNA, Small Interfering
dc.titleA MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.
dc.typeArticle
dcterms.dateAccepted2017-04-26
prism.endingPage606
prism.issueIdentifier7
prism.publicationDate2017
prism.publicationNameNat Struct Mol Biol
prism.startingPage604
prism.volume24
rioxxterms.licenseref.startdate2017-07
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1038/nsmb.3413

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