Repository logo
 

International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Meattini, Icro 
Becherini, Carlotta 
Caini, Saverio 
Coles, Charlotte E 
Cortes, Javier 

Abstract

Novel systemic therapies for breast cancer are being rapidly implemented into clinical practice. These drugs often have different mechanisms of action and side-effect profiles compared with traditional chemotherapy. Underpinning practice-changing clinical trials focused on the systemic therapies under investigation, thus there are sparse data available on radiotherapy. Integration of these new systemic therapies with radiotherapy is therefore challenging. Given this rapid, transformative change in breast cancer multimodal management, the multidisciplinary community must unite to ensure optimal, safe, and equitable treatment for all patients. The aim of this collaborative group of radiation, clinical, and medical oncologists, basic and translational scientists, and patient advocates was to: scope, synthesise, and summarise the literature on integrating novel drugs with radiotherapy for breast cancer; produce consensus statements on drug-radiotherapy integration, where specific evidence is lacking; and make best-practice recommendations for recording of radiotherapy data and quality assurance for subsequent studies testing novel drugs.

Description

Keywords

Humans, Female, Breast Neoplasms, Radiation Oncology, Brachytherapy, Consensus, Physicians

Journal Title

Lancet Oncol

Conference Name

Journal ISSN

1470-2045
1474-5488

Volume Title

25

Publisher

Elsevier BV