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The role of osteoarthritis severity, BMI and age on clinical efficacy of bone marrow aspirate concentrate in the treatment of knee osteoarthritis.

Published version
Peer-reviewed

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Abstract

Aim: The aim of this study was to assess whether BMI, severity of knee osteoarthritis, age and gender have any influence on the final clinical results of bone marrow aspirate concentrate injection. Method: A total of 111 study participants with painful knee osteoarthritis and different characteristics concerning before mentioned factors underwent bone marrow aspirate concentrate (BMAC) therapy and were followed up for 1 year. Result: Significant pain and functional improvement were observed in all participant groups. Participants' age and BMI did not influence the clinical outcome, but there was an influence of OA severity, especially among older patients. Conclusion: This study shows that BMAC therapy is effective. Younger patients with milder OA changes could be better candidates for long-lasting and more efficient BMAC therapy. Clinical Trial Registration: NCT03825133 (ClinicalTrials.gov).

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Keywords

body mass index, bone marrow aspirate concentrate, knee osteoarthritis, osteoarthritis severity, patient's age, regeneration, Humans, Osteoarthritis, Knee, Bone Marrow, Body Mass Index, Bone Marrow Transplantation, Treatment Outcome, Pain

Journal Title

Regen Med

Conference Name

Journal ISSN

1746-0751
1746-076X

Volume Title

18

Publisher

Future Medicine Ltd
Sponsorship
Provincial Government of Vojvodina, New technologies in Medicine, (grant No 231-3/2016)