Phospholipids: pulling back the actin curtain for granule delivery to the immune synapse

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Gawden-Bone, Christian  ORCID logo

Phosphoinositides, together with the phospholipids phosphatidylserine and phosphatidic acid, are important components of the plasma membrane acting as second messengers that, with diacylglycerol, regulate a diverse range of signalling events converting extracellular changes into cellular responses. Local changes in their distribution and membrane charge on the inner leaflet of the plasma membrane play important roles in immune cell function. Here we discuss their distribution and regulators highlighting the importance of membrane changes across the immune synapse on the cytoskeleton and the impact on the function of cytotoxic T lymphocytes.

T cells, cytotoxic T lymphocytes (CTLs), diacylglycerol (DAG), phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), phospholipids, Actins, Cilia, Cytoplasmic Granules, Cytoskeleton, Humans, Immunological Synapses, Metabolic Networks and Pathways, Phospholipids, Signal Transduction, T-Lymphocytes, Cytotoxic
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Frontiers in Immunology
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Frontiers Media
Wellcome Trust (075880/Z/04/A)
Wellcome Trust (103930/Z/14/Z)
Wellcome Trust (100140/Z/12/Z)
Research was funded by Wellcome Trust grants [103930] and [100140], to GMG.