Global Effects of Focal Brain Tumors on Functional Complexity and Network Robustness: A Prospective Cohort Study.


Type
Article
Change log
Authors
Hart, Michael G 
Romero-Garcia, Rafael 
Price, Stephen J 
Abstract

BACKGROUND: Neurosurgical management of brain tumors has entered a paradigm of supramarginal resections that demands thorough understanding of peritumoral functional effects. Historically, the effects of tumors have been believed to be local, and long-range effects have not been considered. OBJECTIVE: To test the hypothesis that tumors affect the brain globally, producing long-range gradients in cortical function. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data were acquired from 11 participants with glioblastoma and split into discovery and validation datasets in a single-center prospective cohort study. Fractal complexity was computed with a wavelet-based estimator of the Hurst exponent. Distance-related effects of the tumors were tested with a tumor mask-dilation technique and parcellation of the underlying Hurst maps. RESULTS: Fractal complexity demonstrates a penumbra of suppression in the peritumoral region. At a global level, as distance from the tumor increases, this initial suppression is balanced by a subsequent overactivity before finally normalizing. These effects were best fit by a quadratic model and were consistent across different network construction pipelines. The Hurst exponent was correlated with graph theory measures of centrality including network robustness, but graph theory measures did not demonstrate distance-dependent effects. CONCLUSION: This work provides evidence supporting the theory that focal brain tumors produce long-range gradients in function. Consequently, the effects of focal lesions need to be interpreted in terms of the global changes on functional complexity and network architecture rather than purely in terms of functional localization. Determining whether peritumoral changes represent potential plasticity may facilitate extended resection of tumors without functional cost.

Description
Keywords
Connectome, Fractal, Functional MRI, Glioblastoma, Neurooncology, Adult, Aged, Brain, Brain Mapping, Brain Neoplasms, Connectome, Female, Fractals, Glioblastoma, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Prospective Studies
Journal Title
Neurosurgery
Conference Name
Journal ISSN
0148-396X
1524-4040
Volume Title
84
Publisher
Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (unknown)
Brain Tumour Charity (GN-000335)
Medical Research Council (MR/M009041/1)
Medical Research Council (MR/M024873/1)
National Institute for Health and Care Research (NIHR/CS/009/011)
MGH is funded by the Wellcome Trust Neuroscience in Psychiatry Network with additional support from the National Institute for Health Research Cambridge Biomedical Research Centre. The imaging studies were funded by an NIHR Clinician Scientist Fellowship for SJP (NIHR/CS/009/011).