jats:titleAbstract</jats:title> jats:pStar formation quenching is one of the key processes that shape the evolution of galaxies. In this study, we investigate the changes in molecular gas and star formation properties as galaxies transit from the star-forming main sequence to the passive regime. Our analysis reveals that as galaxies move away from the main sequence toward the green valley the radial profile of specific star formation rate surface density (Σjats:subsSFR</jats:sub>) is suppressed compared with main-sequence galaxies out to a galactocentric radius of 1.5 jats:italicR</jats:italic> jats:sube</jats:sub>(∼7 kpc for our sample). By combining radial profiles of gas fraction (jats:italicf</jats:italic> jats:subgas</jats:sub>) and star formation efficiency (SFE), we can discern the underlying mechanism that determines Σjats:subsSFR</jats:sub> at different galactocentric radii. Analysis of relative contributions of jats:italicf</jats:italic> jats:subgas</jats:sub> and SFE to Σjats:subsSFR</jats:sub> uncovers a diverse range of quenching modes. Star formation in approximately half of our quenching galaxies is primarily driven by a single mode (i.e., either jats:italicf</jats:italic> jats:subgas</jats:sub> or SFE), or a combination of both. A collective analysis of all galaxies reveals that the reduction in star formation within the central regions (jats:italicR</jats:italic> < 0.5 jats:italicR</jats:italic> jats:sube</jats:sub>) is primarily attributable to a decrease in SFE. Conversely, in the disk regions (jats:italicR</jats:italic> > 0.5 jats:italicR</jats:italic> jats:sube</jats:sub>), both jats:italicf</jats:italic> jats:subgas</jats:sub> and SFE contribute to the suppression of star formation. Our findings suggest that multiple quenching mechanisms may be at play in our sample galaxies, and even within a single galaxy. We also compare our observational outcomes with those from galaxy simulations and discuss the implications of our data.</jats:p>