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Intracranial invasion of a mast cell tumour in a dog: A case report and review of the literature

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Peer-reviewed

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Article

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Authors

Kingsbury, Edward 
Odatzoglou, Petros 
Peschard, Lorraine 
Wong, Hannah 
Elders, Richard 

Abstract

Abstract

Case description: An 11-year-old, female-neutered beagle was presented with a growing soft tissue mass arising within the deep tissues of the left cranial cervical region.

Clinical findings: At presentation, facial asymmetry was evident along with palpable lymphadenomegaly. Magnetic resonance imaging demonstrated a locally invasive cervical mass with intracranial invasion through focal osteolysis of the occipital bone. After antihistamine administration, cytology confirmed mast cell tumour (MCT) with metastasis to local lymph nodes and liver.

Treatment and outcome: The owner chose to pursue lomustine and prednisolone, which were dispensed, but, before home administration, prolonged seizures/status epilepticus occurred prompting euthanasia. Postmortem examination confirmed a high grade MCT associated with, and infiltrating through, muscle, calvarium, dura mata, leptomeninges and the underlying brain.

Clinical Relevance: We present the clinical, imaging, and pathological findings of an unprecedented case of extracranial MCT tumour causing osteolysis of an imperforate flat bone (occipital bone) and intracranial invasion.

Key words: dogs, intracranial, mast cell tumour, osteolysis, metastatic

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Keywords

Journal Title

Veterinary Medicine and Science

Conference Name

Journal ISSN

2053-1095
2053-1095

Volume Title

Publisher

Wiley