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Solid Organ Transplantation From Deceased Donors With Infective Endocarditis: The UK Experience.

Accepted version
Peer-reviewed

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Article

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Authors

Greenhall, George HB 
Robb, Matthew L 
Brown, Chloe 
Johnson, Rachel J 
Tomlinson, Laurie A 

Abstract

BACKGROUND: There is little evidence regarding the use of organs from deceased donors with infective endocarditis. We performed a retrospective analysis of the utilization, safety, and long-term survival of transplants from donors with infective endocarditis in the United Kingdom. METHODS: We studied deceased donor transplants over an 18-y period (2001-2018) using data from the UK Transplant Registry. We estimated the risk of infection transmission, defined as a microbiological isolate in the recipient matching the causative organism in the donor in the first 30 days posttransplant. We examined all-cause allograft failure up to 5 years in kidney and liver recipients, comparing transplants from donors with endocarditis with randomly selected matched control transplants. RESULTS: We studied 88 transplants from 42 donors with infective endocarditis. We found no cases of infection transmission. There was no difference in allograft failure between transplants from donors with infective endocarditis and matched control transplants, among either kidney (hazard ratio, 1.48; 95% CI, 0.66-3.34) or liver (hazard ratio, 1.14; 95% CI, 0.54-2.41) recipients. Compared with matched controls, donors with infective endocarditis donated fewer organs (2.3 versus 3.2 organs per donor; P < 0.001) and were less likely to become kidney donors (odds ratio, 0.29; 95% CI, 0.16-0.55). CONCLUSIONS: We found acceptable safety and long-term allograft survival in transplants from selected donors with infective endocarditis in the United Kingdom. This may have implications for donor selection and organ utilization.

Description

Keywords

Endocarditis, Graft Survival, Humans, Kidney Transplantation, Organ Transplantation, Registries, Retrospective Studies, Tissue Donors, Tissue and Organ Procurement, United Kingdom

Journal Title

Transplantation

Conference Name

Journal ISSN

0041-1337
1534-6080

Volume Title

Publisher

Ovid Technologies (Wolters Kluwer Health)

Rights

All rights reserved