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Genomic analysis of local variation and recent evolution in Plasmodium vivax.

Accepted version
Peer-reviewed

Type

Article

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Authors

Pearson, Richard D 
Amato, Roberto 
Auburn, Sarah 
Miotto, Olivo 
Almagro-Garcia, Jacob 

Abstract

The widespread distribution and relapsing nature of Plasmodium vivax infection present major challenges for the elimination of malaria. To characterize the genetic diversity of this parasite in individual infections and across the population, we performed deep genome sequencing of >200 clinical samples collected across the Asia-Pacific region and analyzed data on >300,000 SNPs and nine regions of the genome with large copy number variations. Individual infections showed complex patterns of genetic structure, with variation not only in the number of dominant clones but also in their level of relatedness and inbreeding. At the population level, we observed strong signals of recent evolutionary selection both in known drug resistance genes and at new loci, and these varied markedly between geographical locations. These findings demonstrate a dynamic landscape of local evolutionary adaptation in the parasite population and provide a foundation for genomic surveillance to guide effective strategies for control and elimination of P. vivax.

Description

Keywords

Biological Evolution, Genetic Markers, Genetic Variation, Genomics, Humans, Malaria, Vivax, Plasmodium vivax

Journal Title

Nat Genet

Conference Name

Journal ISSN

1061-4036
1546-1718

Volume Title

48

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (090770/Z/09/Z)