Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer-specific survival.
cam.issuedOnline | 2018-06 | |
dc.contributor.author | Evans, Andy | |
dc.contributor.author | Sim, Yee Ting | |
dc.contributor.author | Pourreyron, Celine | |
dc.contributor.author | Thompson, Alastair | |
dc.contributor.author | Jordan, Lee | |
dc.contributor.author | Fleming, Dawn | |
dc.contributor.author | Purdie, Colin | |
dc.contributor.author | Macaskill, Jane | |
dc.contributor.author | Vinnicombe, Sarah | |
dc.contributor.author | Pharoah, Paul | |
dc.contributor.orcid | Pharoah, Paul [0000-0001-8494-732X] | |
dc.date.accessioned | 2018-10-10T05:18:13Z | |
dc.date.available | 2018-10-10T05:18:13Z | |
dc.date.issued | 2018-09 | |
dc.description.abstract | INTRODUCTION: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE). METHODS: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression. RESULTS: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P = 0.0001). HR for 2 groups based on US size < or ≥ 20 mm were 1 and 5.1 (P < 0.0001). HR for each unit increase in tumour grade on core biopsy was 3.9 (P < 0.0001). The HR for ER positivity compared to ER negativity was 0.21 (P < 0.001). BCSS was also associated with presentation mode and pre-operative nodal status. In a multivariable model, stiffness, US size and ER status were independently associated with BCSS. CONCLUSION: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions. | |
dc.format.medium | Print-Electronic | |
dc.identifier.doi | 10.17863/CAM.30771 | |
dc.identifier.eissn | 1573-7217 | |
dc.identifier.issn | 0167-6806 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/283403 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.publisher.url | http://dx.doi.org/10.1007/s10549-018-4836-5 | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Breast cancer | |
dc.subject | Neoadjuvant chemotherapy | |
dc.subject | Prognosis | |
dc.subject | Shear wave elastography | |
dc.subject | Ultrasound | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Biomarkers | |
dc.subject | Breast Neoplasms | |
dc.subject | Elasticity | |
dc.subject | Elasticity Imaging Techniques | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Kaplan-Meier Estimate | |
dc.subject | Middle Aged | |
dc.subject | Neoplasm Grading | |
dc.subject | Neoplasm Staging | |
dc.subject | Preoperative Period | |
dc.subject | Prognosis | |
dc.subject | Tumor Microenvironment | |
dc.title | Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer-specific survival. | |
dc.type | Article | |
dcterms.dateAccepted | 2018-05-25 | |
prism.endingPage | 389 | |
prism.issueIdentifier | 2 | |
prism.publicationDate | 2018 | |
prism.publicationName | Breast Cancer Res Treat | |
prism.startingPage | 383 | |
prism.volume | 171 | |
pubs.funder-project-id | Cancer Research Uk (None) | |
rioxxterms.licenseref.startdate | 2018-09 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1007/s10549-018-4836-5 |
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