Recent advances in understanding hypothalamic control of defensive responses to hypoglycaemia
| cam.depositDate | 2022-04-15 | |
| cam.orpheus.counter | 1 | |
| cam.orpheus.success | Wed May 25 11:13:40 BST 2022 - Embargo updated | |
| dc.contributor.author | Evans, Mark | |
| dc.contributor.author | Staricoff, Emily | |
| dc.contributor.orcid | Evans, Mark [0000-0001-8122-8987] | |
| dc.date.accessioned | 2022-04-19T23:30:44Z | |
| dc.date.available | 2022-04-19T23:30:44Z | |
| dc.date.issued | 2022-06 | |
| dc.date.updated | 2022-04-15T17:32:15Z | |
| dc.description.abstract | Maintenance of normal blood glucose is important for survival. In particular, brain function is dependent on circulating glucose. In health, a series of powerful counterregulatory defences operate to prevent/ limit hypoglycaemia. These defences are altered to varying degrees in diabetes and in particular, a subset of people with diabetes can develop profound deficits in these defences placing them at increased risk of suffering episodes of severe hypoglycaemia. Brain is an important controller of glucose homeostasis and developments in molecular techniques have allowed the neurocircuitry of a number of important centrally-controlled homeostatic processes such as energy balance, thirst and thermoregulation to be defined. This review describes how some of these advances have allowed a better understanding of the neuronal/ brain ensembles which help protect against hypoglycaemia. | |
| dc.description.sponsorship | HypoRESOLVE as part of the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 777460. The JU receives support from the European Union’s Horizon 2020 research and innovation | |
| dc.identifier.doi | 10.17863/CAM.83653 | |
| dc.identifier.eissn | 2451-9650 | |
| dc.identifier.issn | 2451-9650 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/336234 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.publisher.department | Department of Medicine | |
| dc.publisher.url | http://dx.doi.org/10.1016/j.coemr.2022.100353 | |
| dc.rights | All Rights Reserved | |
| dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| dc.subject | 3205 Medical Biochemistry and Metabolomics | |
| dc.subject | 32 Biomedical and Clinical Sciences | |
| dc.subject | 3202 Clinical Sciences | |
| dc.subject | Diabetes | |
| dc.subject | Neurosciences | |
| dc.subject | Metabolic and endocrine | |
| dc.title | Recent advances in understanding hypothalamic control of defensive responses to hypoglycaemia | |
| dc.type | Article | |
| dcterms.dateAccepted | 2022-04-15 | |
| prism.publicationName | Current Opinion in Endocrine and Metabolic Research | |
| pubs.licence-display-name | Apollo Repository Deposit Licence Agreement | |
| pubs.licence-identifier | apollo-deposit-licence-2-1 | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | AM | |
| rioxxterms.versionofrecord | 10.1016/j.coemr.2022.100353 |
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