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Deep-Sea Discovery and Detective Work: Towards Solving the Hemicalide Structural Enigma through Computational NMR Analysis and Stereocontrolled Synthesis

cam.issuedOnline2022-06-10
dc.contributor.authorLam, NYS
dc.contributor.authorPaterson, I
dc.contributor.orcidLam, NYS [0000-0002-9307-0619]
dc.contributor.orcidPaterson, I [0000-0002-8861-9136]
dc.date.accessioned2022-06-10T15:00:13Z
dc.date.available2022-06-10T15:00:13Z
dc.date.issued2022
dc.date.submitted2022-04-21
dc.date.updated2022-06-10T15:00:13Z
dc.descriptionFunder: Woolf Fisher
dc.descriptionFunder: Trinity Hall
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>The marine natural product hemicalide displays potent anticancer activity. While detailed NMR experiments established the planar carbon skeleton, its full configurational assignment proved enigmatic. This Review summarises ongoing synthetic efforts and NMR studies on hemicalide, which have succeeded in reducing the number of possible stereoisomers from more than one million to a more manageable eight structures, setting the stage for a focused total synthesis campaign.</jats:p>
dc.identifier.doi10.17863/CAM.85396
dc.identifier.eissn1099-0690
dc.identifier.issn1434-193X
dc.identifier.otherejoc202200467
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337991
dc.languageen
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1002/ejoc.202200467
dc.subjectConfiguration determination
dc.subjectNatural products
dc.subjectNMR spectroscopy
dc.subjectStructure elucidation
dc.subjectTotal synthesis
dc.titleDeep-Sea Discovery and Detective Work: Towards Solving the Hemicalide Structural Enigma through Computational NMR Analysis and Stereocontrolled Synthesis
dc.typeArticle
dcterms.dateAccepted2022-05-24
prism.publicationNameEuropean Journal of Organic Chemistry
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1002/ejoc.202200467

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