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Regional Haemodynamic and Metabolic Coupling in Infants.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Siddiqui, Maheen F 
Pinti, Paola 
Jones, Emily JH 
Brigadoi, Sabrina 

Abstract

Metabolic pathways underlying brain function remain largely unexplored during neurodevelopment, predominantly due to the lack of feasible techniques for use with awake infants. Broadband near-infrared spectroscopy (bNIRS) provides the opportunity to explore the relationship between cerebral energy metabolism and blood oxygenation/haemodynamics through the measurement of changes in the oxidation state of mitochondrial respiratory chain enzyme cytochrome-c-oxidase (ΔoxCCO) alongside haemodynamic changes. We used a bNIRS system to measure ΔoxCCO and haemodynamics during functional activation in a group of 42 typically developing infants aged between 4 and 7 months. bNIRS measurements were made over the right hemisphere over temporal, parietal and central cortical regions, in response to social and non-social visual and auditory stimuli. Both ΔoxCCO and Δ[HbO2] displayed larger activation for the social condition in comparison to the non-social condition. Integration of haemodynamic and metabolic signals revealed networks of stimulus-selective cortical regions that were not apparent from analysis of the individual bNIRS signals. These results provide the first spatially resolved measures of cerebral metabolic activity alongside haemodynamics during functional activation in infants. Measuring synchronised changes in metabolism and haemodynamics have the potential for uncovering the development of cortical specialisation in early infancy.

Description

Keywords

brain metabolic imaging, brain specialization, fNIRS (functional near infrared spectroscopy), metabolism, mitochondria, neurodevelopment, neurovascular coupling, social brain

Journal Title

Front Hum Neurosci

Conference Name

Journal ISSN

1662-5161
1662-5161

Volume Title

15

Publisher

Frontiers Media SA
Sponsorship
MRC (MR/T003057/1)
MRC (MR/S018425/1)
Medical Research Council (MR/K021389/1)
Economic and Social Research Council (ES/R009368/1)