Amplification of actin polymerization forces.

Amplification of actin polymerization forces.

Published version

Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/308554

Repository DOI

https://doi.org/10.17863/CAM.55641

Files

Published version (1.08 MB)

Type

Authors

Dmitrieff, Serge

https://orcid.org/0000-0002-1362-5670

Nédélec, François

Abstract

The actin cytoskeleton drives many essential processes in vivo, using molecular motors and actin assembly as force generators. We discuss here the propagation of forces caused by actin polymerization, highlighting simple configurations where the force developed by the network can exceed the sum of the polymerization forces from all filaments.

Keywords

Actin Cytoskeleton, Actins, Animals, Cell Movement, Humans, Mechanotransduction, Cellular, Models, Biological, Molecular Motor Proteins, Polymerization, Pseudopodia, Stress, Mechanical

Journal Title

J Cell Biol

Journal ISSN

0021-9525
1540-8140

Volume Title

212

Publisher

Rockefeller University Press

Publisher DOI

https://doi.org/10.1083/jcb.201512019

Rights and licensing

Attribution-NonCommercial-ShareAlike 4.0 International

Except where otherwised noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International

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University of Cambridge Research Outputs (Articles and Conferences)