cam.issuedOnline	2021-11-25
dc.contributor.author	Cogni, Rodrigo
dc.contributor.author	Ding, Shuai Dominique
dc.contributor.author	Pimentel, André C
dc.contributor.author	Day, Jonathan
dc.contributor.author	Jiggins, Francis
dc.contributor.orcid	Cogni, Rodrigo [0000-0001-9907-9297]
dc.contributor.orcid	Day, Jonathan [0000-0002-4386-3020]
dc.contributor.orcid	Jiggins, Francis [0000-0001-7470-8157]
dc.date.accessioned	2021-12-15T10:06:58Z
dc.date.available	2021-12-15T10:06:58Z
dc.date.issued	2021-11-25
dc.date.submitted	2021-05-20
dc.date.updated	2021-12-15T10:06:57Z
dc.description.abstract	Wolbachia is a maternally transmitted bacterial symbiont that is estimated to infect approximately half of arthropod species. In the laboratory it can increase the resistance of insects to viral infection, but its effect on viruses in nature is unknown. Here we report that in a natural population of Drosophila melanogaster, individuals that are infected with Wolbachia are less likely to be infected by viruses. By characterising the virome by metagenomic sequencing and then testing individual flies for infection, we found the protective effect of Wolbachia was virus-specific, with the prevalence of infection being up to 15% greater in Wolbachia-free flies. The antiviral effects of Wolbachia may contribute to its extraordinary ecological success, and in nature the symbiont may be an important component of the antiviral defences of insects.
dc.description.sponsorship	Royal Society São Paulo Research Foundation National Council for Scientific and Technological Development (CNPq)
dc.identifier.doi	10.17863/CAM.78879
dc.identifier.eissn	2399-3642
dc.identifier.issn	2399-3642
dc.identifier.other	s42003-021-02838-z
dc.identifier.other	2838
dc.identifier.uri	https://www.repository.cam.ac.uk/handle/1810/331425
dc.language	en
dc.publisher	Springer Science and Business Media LLC
dc.subject	Article
dc.subject	/631/158/855
dc.subject	/631/181/2481
dc.subject	/64/24
dc.subject	/45/90
dc.subject	/45/77
dc.subject	article
dc.title	Wolbachia reduces virus infection in a natural population of Drosophila.
dc.type	Article
dcterms.dateAccepted	2021-10-25
prism.issueIdentifier	1
prism.publicationName	Commun Biol
prism.volume	4
pubs.funder-project-id	Natural Environment Research Council (NE/P00184X/1)
rioxxterms.licenseref.uri	http://creativecommons.org/licenses/by/4.0/
rioxxterms.version	VoR
rioxxterms.versionofrecord	10.1038/s42003-021-02838-z

Wolbachia reduces virus infection in a natural population of Drosophila.

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