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Circulating IRF8-expressing CD123+CD127+ lymphoid progenitors: key players in human hematopoiesis.

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Liang, Kai Ling 
Taghon, Tom 


Lymphopoiesis is the process in which B and T cells, and innate lymphoid cells (ILCs) develop from hematopoietic progenitors that exhibit early lymphoid priming. The branching points where lymphoid-primed human progenitors are further specified to B/T/ILC differentiation trajectories remain unclear. Here, we discuss the emerging role of interferon regulatory factor (IRF)8 as a key factor to bridge human lymphoid and dendritic cell (DC) differentiation, and the current evidence for the existence of circulating and tissue-resident CD123+CD127+ lymphoid progenitors. We propose a model whereby DC/B/T/ILC lineage programs in circulating CD123+CD127+ lymphoid progenitors are expressed in balance. Upon tissue seeding, the tissue microenvironment tilts this molecular balance towards a specific lineage, thereby determining in vivo lineage fates. Finally, we discuss the translational implication of these lymphoid precursors.



IRF8, hematopoiesis, hematopoietic tissues, human, lineage cell fate, lymphoid progenitor cells, Humans, Hematopoiesis, Immunity, Innate, Interferon Regulatory Factors, Interleukin-3 Receptor alpha Subunit, Lymphocytes

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Trends Immunol

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Elsevier BV
Wellcome Trust (107630/Z/15/Z)
Biotechnology and Biological Sciences Research Council (BB/P002293/1)
Wellcome Trust (203151/Z/16/Z)
Wellcome Trust (203151/A/16/Z)
Medical Research Council (MC_PC_17230)