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Metabolic imaging detects resistance to PI3K alpha inhibition mediated by persistent FOXM1 expression in ER+ breast cancer _ Raw data

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Ros Dominguez, Susana  ORCID logo
Wright, Alan J 
Brindle, Kevin M 


  1. Main and supplementary raw data. Zip folder with 7 Excel files containing the raw measurements of main FILE 1 figures 1 (1A,!b,1C,1D,1F,1G,1H,1I), FILE 2 figure 2 (2A,2B,2D,2E,2F), FILE 3 figure 3 (3A,3B,3C,3D,3E,3F,3G), FILE 4 figure4 (4A,4B,4C,4D,4E,4F,4G,4H,4I,4J), FILE 5 figure 6 (6A,6B,6C,6D,6E,6H,6I), FILE 6 figure 7 (7B,7C,7D,7E,7F,7G,7H,7I,7J) and FILE 6 supplementary raw data (Supplementary 1A,1C,2A,2C,2D,2E,2F,2G,3A,3C,3D,3E,3F,3G,4A,4B,4C,4E,4G,5D,5E)
  2. Raw CT and PET data. Zip folder containing the raw DICOM data for the in vivo 18FFDGPET uptake and associated CT experiments.
  3. Raw MRI data. Zip folder containing the raw DICOM data for the in vivo 1-13C hyperpolarized pyruvate - MRI experiments.
  4. Raw Western Blot data. Folder containing the original blots pasted on pdf for figures 1, 2, 3, 4 (in 3 docs 4I, 4II, 4III), 6 and 7; and supplementary figures S2,S3,S4 and S5. See the main manuscript for more details (Open access).


Software / Usage instructions

Excel MATLAB Vivoquant 3.0 software


raw data, imaging, biomarker, FOXM1, PI3K alpha inhibitor, breast cancer, resistance, early detection, MRI


Cancer Research Uk (None)
Cancer Research UK (CB4100)
This work was supported by a CRUK Programme grant (A28289) and by the CRUK-EPSRC Imaging Centre in Cambridge and Manchester (16465) and by NIH grants P30 CA008748 and R01CA190642-01, the Breast Cancer Research Foundation and by grants from Stand Up to Cancer (Cancer Drug Combination Convergence Team), the V Foundation and the National Science Foundation.