The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury.


Type
Article
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Authors
Siripanthong, Bhurint 
Hanff, Thomas C 
Khanji, Mohammed Y 
Abstract

The mechanisms of coronavirus disease-2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.

Description
Keywords
CMR, cardiovascular magnetic resonance, COVID-19, COVID-19, coronavirus disease-2019, CT, Computerized Tomography, LGE, late gadolinium enhancement, MI, myocardial infarction, SARS-CoV-2, severe acute respiratory syndrome coronavirus-2, athlete, cardiovascular magnetic resonance imaging, inflammation, myocardial injury, myocarditis, sudden cardiac death, troponin
Journal Title
JACC Basic Transl Sci
Conference Name
Journal ISSN
2452-302X
2452-302X
Volume Title
Publisher
Elsevier BV