Re-interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation.
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Peer-reviewed
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Authors
Edwards, Paul AW https://orcid.org/0000-0002-4789-3374
Abstract
Much of tumour cell biology and the tumour microenvironment may be normal wound healing responses as a consequence of the disruption of tissue structure. This is why tumours resemble wounds, and many features of the tumour microenvironment, such as the epithelial-mesenchymal transition, cancer-associated fibroblasts, and inflammatory infiltrates, may largely be normal responses to abnormal tissue structure, not an exploitation of wound-healing biology. This article is protected by copyright. All rights reserved.
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Keywords
Tumour microenvironment, cancer, cancer-associated fibroblast, epithelial mesenchymal transition, malignancy, tumour-infiltrating lymphocytes, wound healing
Journal Title
J Pathol
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Journal ISSN
0022-3417
1096-9896
1096-9896
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Publisher
Wiley
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Sponsorship
Breast Cancer Now (2013NovPhD172)
Breast Cancer Now (None)
Cancer Research Uk (None)
Cancer Research Uk (None)
Breast Cancer Now (None)
Cancer Research Uk (None)
Cancer Research Uk (None)