Clinical Characteristics, Treatment, and Short-Term Outcome in Patients with Heart Failure and Cancer.


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Authors
Piotrowski, Jędrzej 
Timler, Małgorzata 
Kozłowski, Remigiusz  ORCID logo  https://orcid.org/0000-0003-2781-5341
Stasiak, Joanna 
Abstract

(1) Our study aimed to look at the clinical characteristics, treatment and short-term outcomes of patients hospitalized due to heart failure with coexisting cancer. (2) Methods: Seventy one cancer (Ca) patients and a randomly selected 70 patients without Ca, hospitalized due to heart failure exacerbation in the same time period constituted the study group (Ca patient group) and controls (non-Ca group), respectively. Data on clinical characteristics were collected retrospectively for both groups. (3) Results: Cancer patients presented with a less advanced NYHA class, had more frequent HFpEF, a higher peak troponin T level, and smaller left atrium size, as compared with controls. The in-hospital deaths of Ca patients were associated with: a higher New York Heart Association (NYHA) class, lower HgB level, worse renal function, higher K and AST levels, presence of diabetes mellitus, and HFpEF. By multivariate logistic regression analysis, impaired renal function was the only independent predictor of in-hospital death in Ca patients (OR-1.15; CI 1.05; 1.27); p = 0.017). The following covariates entered the regression: NYHA class, HgB, GFR, K+, AST, diabetes mellitus t.2, and HFpEF. (4) Conclusions: The clinical picture and the course of heart failure in patients with and without cancer are different.

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Keywords
cancer, heart failure, treatment, short-term outcome
Journal Title
Clin Pract
Conference Name
Journal ISSN
2039-7275
2039-7283
Volume Title
11
Publisher
MDPI AG