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Myosin 10 is involved in murine pigmentation.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Liakath-Ali, Kifayathullah  ORCID logo  https://orcid.org/0000-0001-9047-7424
Vancollie, Valerie E  ORCID logo  https://orcid.org/0000-0003-1547-1975
Sequeira, Inês 
Lelliott, Christopher J  ORCID logo  https://orcid.org/0000-0001-8087-4530

Abstract

Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for Myo10 in pigmentation, with a phenotype unlike those of Myo5a or Myo7a. Adult mice homozygous for a disrupted Myo10 allele on a C57BL/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. Myo10 has previously been implicated in human pigmentation. Our current study reveals involvement of Myo10 in murine skin pigmentation.

Description

Keywords

hair follicles, melanocytes, myosin, pigmentation, Alleles, Animals, Female, Gene Expression, Hair Color, Hair Follicle, Male, Melanocytes, Mice, Mice, Inbred C57BL, Mice, Knockout, Myosins, Penetrance, Pigmentation Disorders, Skin Pigmentation, Syndactyly

Journal Title

Exp Dermatol

Conference Name

Journal ISSN

0906-6705
1600-0625

Volume Title

28

Publisher

Wiley
Sponsorship
Medical Research Council (G0600796)
Medical Research Council (G1100073)