Repository logo
 

A quantitative comparison of in-line coating thickness distributions obtained from a pharmaceutical tablet mixing process using discrete element method and terahertz pulsed imaging

Simple item page
cam.issuedOnline2018-06-18
dc.contributor.authorPei, C
dc.contributor.authorLin, H
dc.contributor.authorMarkl, D
dc.contributor.authorShen, YC
dc.contributor.authorZeitler, JA
dc.contributor.authorElliott, JA
dc.contributor.orcidZeitler, Axel [0000-0002-4958-0582]
dc.contributor.orcidElliott, James [0000-0002-4887-6250]
dc.date.accessioned2018-10-18T10:20:37Z
dc.date.available2018-10-18T10:20:37Z
dc.date.issued2018
dc.description.abstractThe application of terahertz pulsed imaging (TPI) in the in-line configuration to monitor the coating thickness distribution of pharmaceutical tablets has the potential to improve the performance and quality of the spray coating process. In this study, an in-line TPI method is used to measure coating thickness distributions on pre-coated tablets during mixing in a rotating pan, and compared with results obtained numerically using the discrete element method (DEM) combined with a ray-tracing technique. The hit rates (i.e. the number of successful coating thickness measurements per minute) obtained from both terahertz in-line experiments and the DEM/ray-tracing simulations are in good agreement, and both increase with the number of baffles in the mixing pan. We demonstrate that the coating thickness variability as determined from the ray-traced data and the terahertz in-line measurements represents mainly the intra-tablet variability due to relatively uniform mean coating thickness across tablets. The mean coating thickness of the ray-traced data from the numerical simulations agrees well with the mean coating thickness as determined by the off-line TPI measurements. The mean coating thickness of in-line TPI measurements is slightly higher than that of off-line measurements. This discrepancy can be corrected based on the cap-to-band surface area ratio of the tablet and the cap-to-band sampling ratio obtained from ray-tracing simulations: the corrected mean coating thickness of the in-line TPI measurements shows a better agreement with that of off-line measurements.
dc.identifier.doi10.17863/CAM.31471
dc.identifier.eissn1873-4405
dc.identifier.issn0009-2509
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284100
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.urlhttp://dx.doi.org/10.1016/j.ces.2018.06.045
dc.subjectTerahertz in-line sensing
dc.subjectTerahertz pulsed imaging
dc.subjectCoating thickness variability
dc.subjectDiscrete element method
dc.subjectPharmaceutical coating
dc.titleA quantitative comparison of in-line coating thickness distributions obtained from a pharmaceutical tablet mixing process using discrete element method and terahertz pulsed imaging
dc.typeArticle
dcterms.dateAccepted2018-06-15
prism.endingPage45
prism.publicationDate2018
prism.publicationNameChemical Engineering Science
prism.startingPage34
prism.volume192
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/L019922/1)
rioxxterms.licenseref.startdate2018-12-31
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.ces.2018.06.045

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
PeiC_TPI_DEM_r8_text_revised_plain_r1.pdf
Size:
1.47 MB
Format:
Adobe Portable Document Format
Description:
Accepted version
Licence
http://www.rioxx.net/licenses/all-rights-reserved
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
DepositLicenceAgreement.pdf
Size:
417.78 KB
Format:
Adobe Portable Document Format
Download

Collections

Cambridge University Research Outputs