Diastereoselective C-H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams.


Type
Article
Change log
Authors
Png, Zhuang Mao 
Cabrera-Pardo, Jaime R 
Peiró Cadahía, Jorge 
Abstract

A palladium(ii)-catalysed C(sp3)-H carbonylation of free(NH) secondary aliphatic amines to 2-pyrrolidinones is described. A correlation between the nature of the carboxylate ligand and the diastereoselectivity and yield of the process was observed. As such, under these optimal conditions a range of aliphatic amines were converted to the corresponding trans-4,5-disubstituted 2-pyrrolidines with good d.r. and yield.

Description
Keywords
3402 Inorganic Chemistry, 3405 Organic Chemistry, 34 Chemical Sciences
Journal Title
Chem Sci
Conference Name
Journal ISSN
2041-6520
2041-6539
Volume Title
9
Publisher
Royal Society of Chemistry (RSC)
Sponsorship
Engineering and Physical Sciences Research Council (EP/N031792/1)
The Royal Society (wm140104)
European Commission (655856)
EPSRC (EP/N031792/1) Royal Society (Wolfson Award) Agency for Science Technology and Research (A*STAR, Singapore) H2020-MSCA for an International Incoming Fellowship