A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds


Change log
Authors
Poh, Jian‐Siang 
Tran, Duc N 
Battilocchio, Claudio 
Hawkins, Joel M 
Ley, Steven V 
Abstract

jats:titleAbstract</jats:title>jats:pA copper‐catalyzed coupling reaction between flow‐generated unstabilized diazo compounds and terminal alkynes provides di‐ and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.</jats:p>

Description
Keywords
Allene, Carbene, Diazoverbindungen, Durchflusschemie, Kupfer
Journal Title
Angewandte Chemie
Conference Name
Journal ISSN
0044-8249
1521-3757
Volume Title
127
Publisher
Wiley
Sponsorship
Engineering and Physical Sciences Research Council (EP/K039520/1)
We are grateful to the Cambridge Home and European Scholarship Scheme (JSP), Swiss National Science Foundation (DNT), Pfizer Worldwide Research and Development (CB and JMH) and EPSRC (SVL, grant nº EP/K0099494/1 and nº EP/K039520/1) for financial support.