Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration


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Authors
Choi, Jinwook 
Jang, Yu Jin 
Dabrowska, Catherine 
Iich, Elhadi 
Evans, Kelly V 
Abstract

jats:titleAbstract</jats:title>jats:pWhile the acquisition of cellular plasticity in adult stem cells is essential for rapid regeneration after tissue injury, little is known about the underlying molecular mechanisms governing this process. Our data reveal the coordination of airway progenitor differentiation plasticity by inflammatory signals during alveolar regeneration. Upon damage, IL-1β signalling-dependent modulation of Jag1/2 expression in ciliated cells results in the inhibition of Notch signalling in secretory cells, which drives reprogramming and acquisition of differentiation plasticity. We identify a core role for the transcription factor Fosl2/Fra2 in secretory cell fate conversion to alveolar type 2 (AT2) cells retaining the distinct genetic and epigenetic signatures of secretory lineages. We furthermore reveal that KDR/FLK-1jats:sup+</jats:sup> human secretory cells display a conserved capacity to generate AT2 cells via Notch inhibition. Our results demonstrate the functional role of a IL-1β-Notch-Fosl2 axis for the fate decision of secretory cells during injury repair, proposing a new potential therapeutic target for human lung alveolar regeneration.</jats:p>

Description
Keywords
StemCellInstitute
Journal Title
Nature Cell Biology
Conference Name
Journal ISSN
1465-7392
1476-4679
Volume Title
Publisher
Nature Research
Rights
All rights reserved
Sponsorship
Wellcome Trust (098357/Z/12/Z)
Wellcome Trust (107633/Z/15/Z)
Wellcome Trust (203151/Z/16/Z)
European Research Council (679411)
Medical Research Council (MC_PC_17230)