Organoids from adult liver and pancreas: Stem cell biology and biomedical utility.

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Hindley, Christopher J 
Cordero-Espinoza, Lucía 
Huch, Meritxell 

The liver and pancreas are critical organs maintaining whole body metabolism. Historically, the expansion of adult-derived cells from these organs in vitro has proven challenging and this in turn has hampered studies of liver and pancreas stem cell biology, as well as being a roadblock to disease modelling and cell replacement therapies for pathologies in these organs. Recently, defined culture conditions have been described which allow the in vitro culture and manipulation of adult-derived liver and pancreatic material. Here we review these systems and assess their physiological relevance, as well as their potential utility in biomedicine.

3D cultures, Liver, Niche signals, Organoid, Pancreas, Stem cell, Animals, Cell- and Tissue-Based Therapy, Genetic Therapy, Humans, Liver, Liver Regeneration, Models, Biological, Organ Culture Techniques, Organogenesis, Organoids, Pancreas, Signal Transduction, Stem Cells
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Dev Biol
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Elsevier BV
Wellcome Trust (104151/Z/14/Z)
Medical Research Council (MC_PC_12009)
CH is supported by the Herchel Smith Fund. LCE is jointly funded by a Wellcome Trust Four-Year PhD Studentship with the Stem Cell Biology and Medicine Programme and by a Wellcome Cambridge Trust Scholarship. MH is a Wellcome Trust Sir Henry Dale Fellow and is jointly funded by the Wellcome Trust and the Royal Society (104151/Z/14/Z).