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Immune checkpoint inhibitors in resectable gastroesophageal cancers - a review.

Published version
Peer-reviewed

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Authors

Mukherjee, Sarbajit 
Parmar, Kanak 
Smyth, Elizabeth 

Abstract

Gastroesophageal cancers (GEC) have a poor survival rate of 20-30% at 5 years, often due to delayed presentations. Neoadjuvant chemoradiotherapy (CRT) followed by surgery or peri-operative chemotherapy and surgery are widely used as the standard of care for patients with resectable GEC. Immune checkpoint inhibitors (ICIs) have improved survival in metastatic and recurrent GEC which led to their application in resectable GEC. Based on the pivotal CheckMate 577 study results, the Food and Drug Administration (FDA) approved nivolumab for patients with completely resected high-risk esophageal or gastroesophageal junction cancer (GEJC). Several ongoing trials with many ICIs could potentially improve resectable GEC outcomes. This review explores the rationale for using ICIs in resectable GEC and discusses the significance of reported clinical trials. Finally, we will examine some ongoing clinical trials and the challenges as well as prospects of ICIs in resectable GEC.

Description

Peer reviewed: True

Keywords

adjuvant, esophageal cancer, gastric cancer, immunotherapy, neo-adjuvant, nivolumab, pembrolizumab, peri-operative, resectable

Journal Title

Ther Adv Med Oncol

Conference Name

Journal ISSN

1758-8340
1758-8359

Volume Title

Publisher

SAGE Publications