Prognostic models turn the Heat(IT)up on FLT3ITD-mutated AML.


Type
Article
Change log
Authors
Huntly, Brian Jp 
Abstract

The presence of internal tandem duplications (ITDs) in the FLT3 receptor tyrosine kinase gene have long been known to confer a poor prognosis to acute myeloid leukemia (AML) patients. Now, specific structural features of the ITD are also suggested to alter patient outcome, including sensitivity to targeted therapies, prompting their evaluation in therapeutic algorithms.

Description
Keywords
Hot Temperature, Humans, Leukemia, Myeloid, Acute, Prognosis, Tandem Repeat Sequences, fms-Like Tyrosine Kinase 3
Journal Title
Clinical Cancer Research
Conference Name
Journal ISSN
1078-0432
1557-3265
Volume Title
Publisher
American Association for Cancer Research
Sponsorship
Medical Research Council (MC_PC_12009)
Wellcome Trust (109967/Z/15/Z)
Medical Research Council (MR/M010392/1)
Medical Research Council (MR/R009708/1)
European Research Council (647685)
B.J.P. Huntly is supported by The European Research Council (COMAL: 647685) and Cancer Research UK (A25508). P. Gallipoli is supported by the Wellcome Trust (109967/Z/15/Z) and an ASH Global Research Award.