IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.


Type
Article
Change log
Authors
Ryan, Dylan 
Abstract

Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo.

Description
Keywords
IL-10, T cell, exhaustion, immunotherapy, metabolism, mitochondria
Journal Title
Immunometabolism
Conference Name
Journal ISSN
2084-6835
2084-6835
Volume Title
3
Publisher
Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Medical Research Council (MC_UU_12022/6)
Cancer Research UK (A27453)
European Research Council (819920)