Molecular imaging of atherosclerosis with integrated PET imaging


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Authors
Hammad, B 
Evans, NR 
Rudd, JHF 
Tawakol, A 
Abstract

Atherosclerotic diseases account for nearly half of all deaths and are leading causes of adult disability. Our understanding of how atherosclerosis leads to cardiovascular disease events has evolved: from a concept of progressive luminal narrowing, to that of sudden rupture and thrombosis of biologically active atheroma. In concert with this conceptual shift, contemporary imaging techniques now allow imaging of biological processes that associate with plaque instability: active calcification and plaque inflammation. This review focuses on opportunities provided by positron emission tomography/computed tomography, to identify these high-risk biological features of atherosclerosis.

Description
Keywords
atherosclerosis, PET/CT imaging, echocardiography, myocardial perfusion imaging: SPECT, magnetic resonance imaging
Journal Title
Journal of Nuclear Cardiology
Conference Name
Journal ISSN
1071-3581
1532-6551
Volume Title
Publisher
Springer
Sponsorship
Engineering and Physical Sciences Research Council (EP/N014588/1)
British Heart Foundation (None)
British Heart Foundation (None)
The Dunhill Medical Trust (None)
BH is supported by Research Training grant from Alexandria University. NRE is supported by a Research Training Fellowship from The Dunhill Medical Trust [Grant Number RTF44/0114]. JHFR is part supported by the NIHR Cambridge Biomedical Research Centre, the British Heart Foundation, EPSRC, and the Wellcome Trust. AT reports grants from NIH/NHLBI, Actelion, Genentech and Takeda, and personal fees from Actelion, Amgen AstraZeneca, and Takeda, all outside the submitted work.