The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice.

Yura, Yoshimitsu; Miura-Yura, Emiri; Katanasaka, Yasufumi; Min, Kyung-Duk; Chavkin, Nicholas; Polizio, Ariel H; Ogawa, Hayato; Horitani, Keita; Doviak, Heather; Evans, Megan A; Sano, Miho; Wang, Ying; Boroviak, Katharina; Philippos, George; Domingues, Ana Filipa; Vassiliou, George; Sano, Soichi; Walsh, Kenneth

The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice.

Published version

Type

Article

Authors

Yura, Yoshimitsu

Miura-Yura, Emiri

https://orcid.org/0000-0002-5477-5886

Katanasaka, Yasufumi

Min, Kyung-Duk

Chavkin, Nicholas

https://orcid.org/0000-0001-9058-0245

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Abstract

[Figure: see text].

Keywords

CRISPR-Cas Systems, DNA damage, cardiotoxicity, clonal hematopoiesis, heart failure, inflammasome, macrophages, Angiotensin II, Animals, Clonal Hematopoiesis, DNA Damage, Gain of Function Mutation, Heart Failure, Hematopoietic Stem Cells, Inflammasomes, Interleukin-18, Interleukin-1beta, Macrophages, Male, Mice, Mice, Inbred C57BL, NLR Family, Pyrin Domain-Containing 3 Protein, Protein Phosphatase 2C

Journal Title

Circ Res

Journal ISSN

0009-7330
1524-4571

Volume Title

129

Publisher

Ovid Technologies (Wolters Kluwer Health)

Publisher DOI

https://doi.org/10.1161/CIRCRESAHA.121.319314

Rights

Attribution 4.0 International

Sponsorship

Medical Research Council (MC_PC_17230)

Collections

Cambridge University Research Outputs