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The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice.

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cam.depositDate2022-01-14
cam.issuedOnline2021-07-28
dc.contributor.authorYura, Yoshimitsu
dc.contributor.authorMiura-Yura, Emiri
dc.contributor.authorKatanasaka, Yasufumi
dc.contributor.authorMin, Kyung-Duk
dc.contributor.authorChavkin, Nicholas
dc.contributor.authorPolizio, Ariel H
dc.contributor.authorOgawa, Hayato
dc.contributor.authorHoritani, Keita
dc.contributor.authorDoviak, Heather
dc.contributor.authorEvans, Megan A
dc.contributor.authorSano, Miho
dc.contributor.authorWang, Ying
dc.contributor.authorBoroviak, Katharina
dc.contributor.authorPhilippos, George
dc.contributor.authorDomingues, Ana Filipa
dc.contributor.authorVassiliou, George
dc.contributor.authorSano, Soichi
dc.contributor.authorWalsh, Kenneth
dc.contributor.orcidMiura-Yura, Emiri [0000-0002-5477-5886]
dc.contributor.orcidChavkin, Nicholas [0000-0001-9058-0245]
dc.contributor.orcidPhilippos, George [0000-0002-8433-9719]
dc.contributor.orcidVassiliou, George [0000-0003-4337-8022]
dc.contributor.orcidWalsh, Kenneth [0000-0001-7580-2276]
dc.date.accessioned2022-01-15T00:31:15Z
dc.date.available2022-01-15T00:31:15Z
dc.date.issued2021-09-03
dc.date.updated2022-01-14T13:49:53Z
dc.description.abstract[Figure: see text].
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.80179
dc.identifier.eissn1524-4571
dc.identifier.issn0009-7330
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332738
dc.language.isoeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.publisher.departmentDepartment of Haematology
dc.publisher.urlhttp://dx.doi.org/10.1161/circresaha.121.319314
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCRISPR-Cas Systems
dc.subjectDNA damage
dc.subjectcardiotoxicity
dc.subjectclonal hematopoiesis
dc.subjectheart failure
dc.subjectinflammasome
dc.subjectmacrophages
dc.subjectAngiotensin II
dc.subjectAnimals
dc.subjectClonal Hematopoiesis
dc.subjectDNA Damage
dc.subjectGain of Function Mutation
dc.subjectHeart Failure
dc.subjectHematopoietic Stem Cells
dc.subjectInflammasomes
dc.subjectInterleukin-18
dc.subjectInterleukin-1beta
dc.subjectMacrophages
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectNLR Family, Pyrin Domain-Containing 3 Protein
dc.subjectProtein Phosphatase 2C
dc.titleThe Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice.
dc.typeArticle
prism.endingPage698
prism.issueIdentifier6
prism.publicationDate2021
prism.publicationNameCirc Res
prism.startingPage684
prism.volume129
pubs.funder-project-idMedical Research Council (MC_PC_17230)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1161/CIRCRESAHA.121.319314

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