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The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Reference Genome Group of the Gene Ontology Consortium 

Abstract

The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene function across different organisms. Each contributing member of the GO Consortium independently associates GO terms to gene products from the organism(s) they are annotating. Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms. The Reference Genome project has two primary goals: to increase the depth and breadth of annotations for genes in each of the organisms in the project, and to create data sets and tools that enable other genome annotation efforts to infer GO annotations for homologous genes in their organisms. In addition, the project has several important incidental benefits, such as increasing annotation consistency across genome databases, and providing important improvements to the GO's logical structure and biological content.

Description

Keywords

Animals, Cluster Analysis, Database Management Systems, Databases, Genetic, Genomics, Humans, Vocabulary, Controlled

Journal Title

PLoS Comput Biol

Conference Name

Journal ISSN

1553-734X
1553-7358

Volume Title

5

Publisher

Public Library of Science (PLoS)
Sponsorship
Wellcome Trust (090548/Z/09/Z)
Medical Research Council (G0500293)
National Human Genome Research Institute (U41HG002659)