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Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive index

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cam.issuedOnline2017-04-02
dc.contributor.authorChakraborty, M
dc.contributor.authorRidgway, C
dc.contributor.authorBawuah, P
dc.contributor.authorMarkl, D
dc.contributor.authorGane, PAC
dc.contributor.authorKetolainen, J
dc.contributor.authorZeitler, JA
dc.contributor.authorPeiponen, K-E
dc.contributor.orcidBawuah, Prince [0000-0001-7688-0065]
dc.contributor.orcidMarkl, Daniel [0000-0003-0411-733X]
dc.contributor.orcidZeitler, Axel [0000-0002-4958-0582]
dc.date.accessioned2017-07-06T12:20:39Z
dc.date.available2017-07-06T12:20:39Z
dc.date.issued2017-06-15
dc.description.abstractThe objective of this study is to propose a novel optical compressibility parameter for porous pharmaceutical tablets. This parameter is defined with the aid of the effective refractive index of a tablet that is obtained from non-destructive and contactless terahertz (THz) time-delay transmission measurement. The optical compressibility parameter of two training sets of pharmaceutical tablets with $\textit{a priori}$ known porosity and mass fraction of a drug was investigated. Both pharmaceutical sets were compressed with one of the most commonly used excipients, namely microcrystalline cellulose (MCC) and drug Indomethacin. The optical compressibility clearly correlates with the skeletal bulk modulus determined by mercury porosimetry and the recently proposed terahertz lumped structural parameter calculated from terahertz measurements. This lumped structural parameter can be used to analyse the pattern of arrangement of excipient and drug particles in porous pharmaceutical tablets. Therefore, we propose that the optical compressibility can serve as a quality parameter of a pharmaceutical tablet corresponding with the skeletal bulk modulus of the porous tablet, which is related to structural arrangement of the powder particles in the tablet.
dc.identifier.doi10.17863/CAM.11259
dc.identifier.eissn1873-3476
dc.identifier.issn0378-5173
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265203
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.publisher.urlhttp://dx.doi.org/10.1016/j.ijpharm.2017.03.093
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectindomethacin
dc.subjectmicrocrystalline cellulose
dc.subjectoptical compressibility
dc.subjectpharmaceutical tablet
dc.subjectskeletal bulk modulus
dc.subjectstructural parameter
dc.subjectterahertz
dc.titleOptics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive index
dc.typeArticle
dcterms.dateAccepted2017-03-31
prism.endingPage91
prism.issueIdentifier1
prism.publicationDate2017
prism.publicationNameInternational Journal of Pharmaceutics
prism.startingPage85
prism.volume525
rioxxterms.licenseref.startdate2017-06-15
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.ijpharm.2017.03.093

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