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Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Published version
Peer-reviewed

Change log

Authors

Kaitu’u-Lino, Tu’uhevaha J. 
MacDonald, Teresa M.  ORCID logo  https://orcid.org/0000-0001-9099-7745
Cannon, Ping 
Nguyen, Tuong-Vi 
Hiscock, Richard J. 

Abstract

Abstract: Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially near-term gestation when the risk of stillbirth rises. Here we show a strong association between low circulating plasma serine peptidase inhibitor Kunitz type-1 (SPINT1) concentrations at 36 weeks’ gestation and low birthweight, an indicator of placental insufficiency. We generate a 4-tier risk model based on SPINT1 concentrations, where the highest risk tier has approximately a 2-5 fold risk of birthing neonates with birthweights under the 3rd, 5th, 10th and 20th centiles, whereas the lowest risk tier has a 0-0.3 fold risk. Low SPINT1 is associated with antenatal ultrasound and neonatal anthropomorphic indicators of placental insufficiency. We validate the association between low circulating SPINT1 and placental insufficiency in two other cohorts. Low circulating SPINT1 is a marker of placental insufficiency and may identify pregnancies with an elevated risk of stillbirth.

Description

Funder: RANZCOG Research Foundation (RANZCOG); doi: https://doi.org/10.13039/501100001104


Funder: The Stillbirth Foundation


Funder: Tommy's; doi: https://doi.org/10.13039/501100009324


Funder: National Institute Health Research Manchester Academic Health Science Centre


Funder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi.org/10.13039/501100000268


Funder: Centre for Trophoblast Research

Keywords

Article, /692/53, /692/699, /38, /82/80, /38/88, article

Journal Title

Nature Communications

Conference Name

Journal ISSN

2041-1723

Volume Title

11

Publisher

Nature Publishing Group UK
Sponsorship
Department of Health | National Health and Medical Research Council (NHMRC) (1105603, 1065854, 1136418, 1183854)