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Adolescent development of multiscale structural wiring and functional interactions in the human connectome.

Published version
Peer-reviewed

Repository DOI


Type

Article

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Authors

Paquola, Casey 
Bethlehem, Richard AI  ORCID logo  https://orcid.org/0000-0002-0714-0685
Neuroscience in Psychiatry Network (NSPN) Consortium 

Abstract

Adolescence is a time of profound changes in the physical wiring and function of the brain. Here, we analyzed structural and functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y (n = 199). Core to our work was an advanced in vivo model of cortical wiring incorporating MRI features of corticocortical proximity, microstructural similarity, and white matter tractography. Longitudinal analyses assessing age-related changes in cortical wiring identified a continued differentiation of multiple corticocortical structural networks in youth. We then assessed structure-function coupling using resting-state functional MRI measures in the same participants both via cross-sectional analysis at baseline and by studying longitudinal change between baseline and follow-up scans. At baseline, regions with more similar structural wiring were more likely to be functionally coupled. Moreover, correlating longitudinal structural wiring changes with longitudinal functional connectivity reconfigurations, we found that increased structural differentiation, particularly between sensory/unimodal and default mode networks, was reflected by reduced functional interactions. These findings provide insights into adolescent development of human brain structure and function, illustrating how structural wiring interacts with the maturation of macroscale functional hierarchies.

Description

Keywords

brain development, connectome, cortical gradients, structure function, Adolescent, Adolescent Development, Brain, Connectome, Cross-Sectional Studies, Humans, Magnetic Resonance Imaging, Nerve Net

Journal Title

Proc Natl Acad Sci U S A

Conference Name

Journal ISSN

0027-8424
1091-6490

Volume Title

119

Publisher

Proceedings of the National Academy of Sciences
Sponsorship
Medical Research Council (MR/M009041/1)