This paper considers the processes in the illicit online prescription drug trade, namely search-redirection attacks and the operation of unlicensed pharmacies using crime script analysis. Empirical data have been used to describe the salient elements of the online criminal infrastructures and associated monetization paths enabling criminal profitability. This analysis reveals the existence of structural chokepoints: components of online criminal operations being limited in number, and critical for the operations’ profitability. Consequently, interventions targeting such components can reduce the opportunities and incentives to engage in online crime through an increase in criminal operational costs, and in the risk of apprehension.