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Circuits for integrating learned and innate valences in the insect brain.

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cam.issuedOnline2021-11-10
dc.contributor.authorEschbach, Claire
dc.contributor.authorFushiki, Akira
dc.contributor.authorWinding, Michael
dc.contributor.authorAfonso, Bruno
dc.contributor.authorAndrade, Ingrid V
dc.contributor.authorCocanougher, Benjamin T
dc.contributor.authorEichler, Katharina
dc.contributor.authorGepner, Ruben
dc.contributor.authorSi, Guangwei
dc.contributor.authorValdes-Aleman, Javier
dc.contributor.authorFetter, Richard D
dc.contributor.authorGershow, Marc
dc.contributor.authorJefferis, Gregory Sxe
dc.contributor.authorSamuel, Aravinthan Dt
dc.contributor.authorTruman, James W
dc.contributor.authorCardona, Albert
dc.contributor.authorZlatic, Marta
dc.contributor.orcidEschbach, Claire [0000-0002-8092-3440]
dc.contributor.orcidFushiki, Akira [0000-0002-7987-6405]
dc.contributor.orcidWinding, Michael [0000-0003-1965-3266]
dc.contributor.orcidCocanougher, Benjamin T [0000-0003-0648-554X]
dc.contributor.orcidEichler, Katharina [0000-0002-7833-8621]
dc.contributor.orcidFetter, Richard D [0000-0002-1558-100X]
dc.contributor.orcidGershow, Marc [0000-0001-7528-6101]
dc.contributor.orcidJefferis, Gregory Sxe [0000-0002-0587-9355]
dc.contributor.orcidSamuel, Aravinthan Dt [0000-0002-1672-8720]
dc.contributor.orcidTruman, James W [0000-0002-9209-5435]
dc.contributor.orcidCardona, Albert [0000-0003-4941-6536]
dc.contributor.orcidZlatic, Marta [0000-0002-3149-2250]
dc.date.accessioned2022-01-07T16:47:07Z
dc.date.available2022-01-07T16:47:07Z
dc.date.issued2021-11-10
dc.date.updated2022-01-07T16:47:06Z
dc.descriptionFunder: Howard Hughes Medical Institute
dc.description.abstractAnimal behavior is shaped both by evolution and by individual experience. Parallel brain pathways encode innate and learned valences of cues, but the way in which they are integrated during action-selection is not well understood. We used electron microscopy to comprehensively map with synaptic resolution all neurons downstream of all mushroom body (MB) output neurons (encoding learned valences) and characterized their patterns of interaction with lateral horn (LH) neurons (encoding innate valences) in Drosophila larva. The connectome revealed multiple convergence neuron types that receive convergent MB and LH inputs. A subset of these receives excitatory input from positive-valence MB and LH pathways and inhibitory input from negative-valence MB pathways. We confirmed functional connectivity from LH and MB pathways and behavioral roles of two of these neurons. These neurons encode integrated odor value and bidirectionally regulate turning. Based on this, we speculate that learning could potentially skew the balance of excitation and inhibition onto these neurons and thereby modulate turning. Together, our study provides insights into the circuits that integrate learned and innate valences to modify behavior.
dc.identifier.doi10.17863/CAM.79776
dc.identifier.eissn2050-084X
dc.identifier.issn2050-084X
dc.identifier.otherPMC8616581
dc.identifier.other34755599
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332330
dc.languageeng
dc.language.isoeng
dc.publishereLife Sciences Publications, Ltd
dc.publisher.urlhttp://dx.doi.org/10.7554/elife.62567
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2050-084X
dc.sourcenlmid: 101579614
dc.subjectD. melanogaster
dc.subjectaction selection
dc.subjectconnectome
dc.subjectlearnt behavior
dc.subjectneuroscience
dc.subjectvalence
dc.subjectAnimals
dc.subjectBrain
dc.subjectConnectome
dc.subjectDrosophila melanogaster
dc.subjectLarva
dc.subjectLearning
dc.subjectMushroom Bodies
dc.subjectNeurons
dc.titleCircuits for integrating learned and innate valences in the insect brain.
dc.typeArticle
dcterms.dateAccepted2021-11-03
prism.publicationNameElife
prism.volume10
pubs.funder-project-idWellcome Trust (205050/Z/16/Z)
pubs.funder-project-idWellcome Trust (205038/Z/16/Z)
pubs.funder-project-idEuropean Research Council (819650)
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.7554/eLife.62567

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