Repository logo
 

Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Hückesfeld, Sebastian  ORCID logo  https://orcid.org/0000-0003-0236-6375
Miroschnikow, Anton  ORCID logo  https://orcid.org/0000-0002-2276-3434
Zinke, Ingo 

Abstract

Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the periphery, the synaptic inputs onto these neuroendocrine outputs in the brain are less well understood. Here, we use the transmission electron microscopy reconstruction of a whole central nervous system in the Drosophila larva to elucidate the sensory pathways and the interneurons that provide synaptic input to the neurosecretory cells projecting to the endocrine organs. Predicted by network modeling, we also identify a new carbon dioxide-responsive network that acts on a specific set of neurosecretory cells and that includes those expressing corazonin (Crz) and diuretic hormone 44 (Dh44) neuropeptides. Our analysis reveals a neuronal network architecture for combinatorial action based on sensory and interneuronal pathways that converge onto distinct combinations of neuroendocrine outputs.

Description

Keywords

D. melanogaster, carbon dioxide, connectome, interneuron, neuroendocrine system, neuropeptides, neuroscience, sensory synapses, Animals, Animals, Genetically Modified, Carbon Dioxide, Connectome, Drosophila Proteins, Drosophila melanogaster, Insect Hormones, Interneurons, Microscopy, Electron, Transmission, Neuropeptides, Neurosecretory Systems, Sensory Receptor Cells, Synapses

Journal Title

Elife

Conference Name

Journal ISSN

2050-084X
2050-084X

Volume Title

10

Publisher

eLife Sciences Publications, Ltd
Sponsorship
Wellcome Trust (205038/Z/16/Z)