Transforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma.
| cam.issuedOnline | 2022-03-31 | |
| dc.contributor.author | Timmins, Matthew A | |
| dc.contributor.author | Ringshausen, Ingo | |
| dc.contributor.orcid | Timmins, Matthew A [0000-0002-7127-7395] | |
| dc.contributor.orcid | Ringshausen, Ingo [0000-0002-7247-311X] | |
| dc.date.accessioned | 2022-04-02T01:01:41Z | |
| dc.date.available | 2022-04-02T01:01:41Z | |
| dc.date.issued | 2022-03-31 | |
| dc.date.updated | 2022-04-02T01:01:40Z | |
| dc.description.abstract | Transforming growth factor-beta (TGFB) is a critical regulator of normal haematopoiesis. Dysregulation of the TGFB pathway is associated with numerous haematological malignancies including myelofibrosis, acute myeloid leukaemia, and lymphoid disorders. TGFB has classically been seen as a negative regulator of proliferation in haematopoiesis whilst stimulating differentiation and apoptosis, as required to maintain homeostasis. Tumours frequently develop intrinsic resistant mechanisms to homeostatic TGFB signalling to antagonise its tumour-suppressive functions. Furthermore, elevated levels of TGFB enhance pathogenesis through modulation of the immune system and tumour microenvironment. Here, we review recent advances in the understanding of TGFB signalling in B-cell malignancies with a focus on the tumour microenvironment. Malignant B-cells harbour subtype-specific alterations in TGFB signalling elements including downregulation of surface receptors, modulation of SMAD signalling proteins, as well as genetic and epigenetic aberrations. Microenvironmental TGFB generates a protumoural niche reprogramming stromal, natural killer (NK), and T-cells. Increasingly, evidence points to complex bi-directional cross-talk between cells of the microenvironment and malignant B-cells. A greater understanding of intercellular communication and the context-specific nature of TGFB signalling may provide further insight into disease pathogenesis and future therapeutic strategies. | |
| dc.identifier.doi | 10.17863/CAM.83137 | |
| dc.identifier.eissn | 2072-6694 | |
| dc.identifier.issn | 2072-6694 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/335701 | |
| dc.language | en | |
| dc.publisher | MDPI AG | |
| dc.subject | TGFB | |
| dc.subject | B-cell lymphoma | |
| dc.subject | microenvironment | |
| dc.title | Transforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma. | |
| dc.type | Article | |
| dcterms.dateAccepted | 2022-03-23 | |
| prism.issueIdentifier | 7 | |
| prism.publicationName | Cancers (Basel) | |
| prism.volume | 14 | |
| rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0/ | |
| rioxxterms.version | VoR | |
| rioxxterms.versionofrecord | 10.3390/cancers14071772 |
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