Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase


Type
Article
Change log
Authors
Aleeva, Y 
Maira, G 
Scopelliti, M 
Vinciguerra, V 
Scandurra, G 
Abstract

Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 \mu \text{A}/({\mathrm {mM}} \cdot {\mathrm {cm}}^{2}) are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (fluctuation-enhanced sensing).

Description
Keywords
Amperometric sensors, biosensors, chemical and biological sensors, conductive films, polymer films, remote sensing, thick film biosensors
Journal Title
IEEE Sensors Journal
Conference Name
Journal ISSN
1530-437X
1558-1748
Volume Title
18
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Sponsorship
Luigi