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Myocardial Fibrosis in Heart Failure: Anti-Fibrotic Therapies and the Role of Cardiovascular Magnetic Resonance in Drug Trials.

Published version
Peer-reviewed

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Type

Article

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Authors

Webber, Matthew 
Jackson, Stephen P 
Moon, James C 

Abstract

All heart muscle diseases that cause chronic heart failure finally converge into one dreaded pathological process that is myocardial fibrosis. Myocardial fibrosis predicts major adverse cardiovascular events and death, yet we are still missing the targeted therapies capable of halting and/or reversing its progression. Fundamentally it is a problem of disproportionate extracellular collagen accumulation that is part of normal myocardial ageing and accentuated in certain disease states. In this article we discuss the role of cardiovascular magnetic resonance (CMR) imaging biomarkers to track fibrosis and collate results from the most promising animal and human trials of anti-fibrotic therapies to date. We underscore the ever-growing role of CMR in determining the efficacy of such drugs and encourage future trialists to turn to CMR when designing their surrogate study endpoints.

Description

Keywords

Anti-fibrotic therapies, Cardiac magnetic resonance imaging, Extracellular volume, Myocardial fibrosis, T1 mapping

Journal Title

Cardiol Ther

Conference Name

Journal ISSN

2193-8261
2193-6544

Volume Title

9

Publisher

Springer Science and Business Media LLC
Sponsorship
Cancer Research UK (18796)